Komatsu Research
Our laboratory focuses on developing translational strategies to improve the success of cell and tissue transplantation. We combine quantitative biology with engineering approaches to address key physiological and technical barriers that limit clinical application.
We develop clinically grounded approaches to restore tissue function through therapeutic cell and tissue transplantation, with an emphasis on safety, durability, and translational feasibility. Our work explores alternative implantation sites and delivery strategies that reduce invasiveness while maintaining or improving
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We study oxygen dynamics in three-dimensional cellular systems, including spheroids, organoids, and transplanted grafts. By quantifying oxygen distribution and defining survival thresholds, we aim to identify critical design constraints that influence cell viability and function in both in vitro and
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We develop large-scale three-dimensional tissue constructs and organoids, addressing diffusion limitations that have traditionally restricted their size and clinical applicability. By integrating controlled oxygen delivery strategies, we aim to enable the generation of viable, functional tissues at scales relevant for
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We design biomimetic platforms and implantable devices that enhance oxygen delivery and regulate the cellular microenvironment. These technologies are intended to support minimally invasive transplantation approaches and enable scalable fabrication of engineered tissues.
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