Komatsu Lab - Homepage
Hirotake Komatsu, MD, PhD
Principal Investigator
Associate Professor
Division of Transplant Surgery
Department of Surgery
Komatsu Lab
Reimagining cell transplantation through engineered oxygen microenvironments
The Komatsu Laboratory pioneers next-generation strategies in regenerative medicine by addressing one of the most fundamental barriers in cell therapy: oxygen limitation. By integrating tissue engineering, transplant biology, and bioengineering, we design microenvironments that enable therapeutic cells to survive, function, and integrate in vivo.
Our work focuses on transforming how cell and tissue transplantation is performed, with the goal of making durable, clinically effective therapies a reality. Through multidisciplinary innovation, we aim to bridge the gap between experimental biology and real-world treatment, advancing curative approaches for diseases such as diabetes.
Featured News
Publications
- Advances in Beta-cell Replacement Therapy for Diabetes-Insights From the 20th International Pancreas and Islet Transplant Association (IPITA) World Congress, Pisa, 2025.
2026 |
PubMed
- Enhanced hypoxia resistance distinguishes human pluripotent stem cell-derived islets from primary islets.
2026 |PubMed
- Donation After Circulatory Death Islets are Comparable to Standard-of-Care Donation After Brain Death Islets: Analysis of 801 Consecutive Human Islet Isolations.
2026 |PubMed
- Long-term culture of human pancreatic islets reveals reduced metal ion pathways in their gene signature.
2025 |PubMed
- Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy.
2025 |PubMed
Our laboratory focuses on developing translational strategies to improve the success of cell and tissue transplantation. We combine quantitative biology with engineering approaches to address key physiological and technical barriers that limit clinical application.
