University of California San Francisco

Publications

  1. Advances in Beta-cell Replacement Therapy for Diabetes-Insights From the 20th International Pancreas and Islet Transplant Association (IPITA) World Congress, Pisa, 2025.
    Rao JS, Barra JM, Parmentier C, Chaudhry A, Doherty D, Komatsu H, Mitsugashira H, Citro A, Nijhoff MF, Piemonti L, Scholz H
    Transplantation. 2026 Apr 03.; 
    PubMed
  2. Enhanced hypoxia resistance distinguishes human pluripotent stem cell-derived islets from primary islets.
    Kato H, Shang KM, Mitsugashira H, Qi M, Suzuki T, Stock PG, Toyoda T, Tai YC, Kandeel F, Komatsu H
    Am J Physiol Cell Physiol. 2026 Mar 23.; 
    PubMed
  3. Donation After Circulatory Death Islets are Comparable to Standard-of-Care Donation After Brain Death Islets: Analysis of 801 Consecutive Human Islet Isolations.
    Qi M, Omori K, Orr C, Valiente L, Bilbao S, Tucker A, Rawson J, Gonzalez N, Verret J, Cuadra J, Mares J, Jou K, Ligot D, Balandran B, Komatsu H, Mehra M, Ramos K, Hacker-Stratton J, Al-Abdullah IH, Isenberg JS, Kandeel F
    Transplant Direct. 2026 Apr; 12(4):e1930.; 
    PubMed
  4. Long-term culture of human pancreatic islets reveals reduced metal ion pathways in their gene signature.
    Kato H, Sigdel TK, Sheta M, Omori K, Qi M, Kandeel F, Komatsu H
    Cell Transplant. 2025 Jan-Dec; 34:9636897251390960.; 
    PubMed
  5. Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy.
    Shang KM, Suzuki T, Kato H, Toyoda T, Tai YC, Komatsu H
    Am J Physiol Cell Physiol. 2025 May 01; 328(5):C1667-C1684.; 
    PubMed
  6. Characterization of Human Pancreatic Islet Cells Using a Single-Cell Western Blot Platform.
    Lenz G, Miao L, Lenz A, Mares J, Quijano J, Zook HN, Komatsu H, Garcia P, Ferreri K, Ku HT, Kandeel F
    Pancreas. 2024 Nov-Dec 01; 53(10):e818-e829.; 
    PubMed
  7. Biological hypoxia in pre-transplant human pancreatic islets induces transplant failure in diabetic mice.
    Kato H, Salgado M, Mendez D, Gonzalez N, Rawson J, Ligot D, Balandran B, Orr C, Quijano JC, Omori K, Qi M, Al-Abdullah IH, Mullen Y, Ku HT, Kandeel F, Komatsu H
    Sci Rep. 2024 05 30; 14(1):12402.; 
    PubMed
  8. A novel approach to determine the critical survival threshold of cellular oxygen within spheroids via integrating live/dead cell imaging with oxygen modeling.
    Shang KM, Kato H, Gonzalez N, Kandeel F, Tai YC, Komatsu H
    Am J Physiol Cell Physiol. 2024 04 01; 326(4):C1262-C1271.; 
    PubMed
  9. Firefly Rats: Illuminating the Scientific Community in Transplantation Research.
    Kobayashi E, Hakamata Y, Enosawa S, Shang KM, Komatsu H
    Cell Transplant. 2024 Jan-Dec; 33:9636897231224174.; 
    PubMed
  10. Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets.
    Kato H, Chen H, Shang KM, Izumi K, Koba N, Tsuchiya T, Kawazoe N, Quijano J, Omori K, Orr C, Qi M, Ku HT, Kandeel F, Tai YC, Chen G, Komatsu H
    Cell Transplant. 2024 Jan-Dec; 33:9636897241249556.; 
    PubMed
  11. A scalable human islet 3D-culture platform maintains cell mass and function long-term for transplantation.
    Omori K, Qi M, Salgado M, Gonzalez N, Hui LT, Chen KT, Rawson J, Miao L, Komatsu H, Isenberg JS, Al-Abdullah IH, Mullen Y, Kandeel F
    Am J Transplant. 2024 Feb; 24(2):177-189.; 
    PubMed
  12. Ubiquitous Luciferase Expression in "Firefly Rats" Does Not Alter the Pancreatic Islet Morphology, Metabolism, and Function.
    Gonzalez N, Kato H, Tixi W, Ortiz J, Orr C, Shih HP, Ku HT, Yee JK, Kandeel F, Mullen Y, Kobayashi E, Komatsu H
    Cell Transplant. 2023 Jan-Dec; 32:9636897231182497.; 
    PubMed
  13. Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets.
    Myrick RJ, Shang KM, Betts JF, Gonzalez N, Rawson J, Izumi K, Koba N, Tsuchiya T, Kato H, Omori K, Kandeel F, Mullen Y, Tai YC, Botvinick E, Komatsu H
    Biofabrication. 2022 12 20; 15(1).; 
    PubMed
  14. Microwell culture platform maintains viability and mass of human pancreatic islets.
    Kato H, Miwa T, Quijano J, Medrano L, Ortiz J, Desantis A, Omori K, Wada A, Tatsukoshi K, Kandeel F, Mullen Y, Ku HT, Komatsu H
    Front Endocrinol (Lausanne). 2022; 13:1015063.; 
    PubMed
  15. Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival.
    Omori K, Gonzalez I, Nguyen C, Raminani SN, Deleon VM, Meza P, Zamalloa J, Perez RG, Gonzalez N, Komatsu H, Al-Abdullah IH, Wen X
    Biomolecules. 2022 10 28; 12(11).; 
    PubMed
  16. Biodistribution of Intra-Arterial and Intravenous Delivery of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in a Rat Model to Guide Delivery Strategies for Diabetes Therapies.
    Li J, Komatsu H, Poku EK, Olafsen T, Huang KX, Huang LA, Chea J, Bowles N, Chang B, Rawson J, Peng J, Wu AM, Shively JE, Kandeel FR
    Pharmaceuticals (Basel). 2022 May 12; 15(5).; 
    PubMed
  17. Critical Considerations in Bioluminescence Imaging of Transplanted Islets: Dynamic Signal Change in Early Posttransplant Phase and Signal Absorption by Tissues.
    Komatsu H, Kobayashi E, Gonzalez N, Rawson J, Ortiz J, Donohue C, Ku HT, Kandeel F, Mullen Y
    Pancreas. 2022 03 01; 51(3):234-242.; 
    PubMed
  18. A Multiparametric Assessment of Human Islets Predicts Transplant Outcomes in Diabetic Mice.
    Komatsu H, Qi M, Gonzalez N, Salgado M, Medrano L, Rawson J, Orr C, Omori K, Isenberg JS, Kandeel F, Mullen Y, Al-Abdullah IH
    Cell Transplant. 2021 Jan-Dec; 30:9636897211052291.; 
    PubMed
  19. Early-Phase Luciferase Signals of Islet Grafts Predicts Successful Subcutaneous Site Transplantation in Rats.
    Komatsu H, Gonzalez N, Ortiz J, Rawson J, Omori K, Kandeel F, Mullen Y
    Mol Imaging Biol. 2021 04; 23(2):173-179.; 
    PubMed
  20. Intermittent normobaric oxygen inhalation enhances subcutaneous prevascularization for cell transplantation.
    Komatsu H, Gonzalez N, Kandeel F, Mullen Y
    Microvasc Res. 2020 11; 132:104070.; 
    PubMed
  21. High Fractions of Large Islets in Human Islet Preparations Detrimentally Affect Posttransplant Outcomes in Streptozotocin-Induced Diabetic Immunodeficient Mice.
    Komatsu H, Salgado M, Gonzalez N, Medrano L, Rawson J, Omori K, Qi M, Al-Abdullah I, Kandeel F, Mullen Y
    Pancreas. 2020 May/Jun; 49(5):650-654.; 
    PubMed
  22. A subcutaneous pancreatic islet transplantation platform using a clinically applicable, biodegradable Vicryl mesh scaffold - an experimental study.
    Komatsu H, Gonzalez N, Salgado M, Cook CA, Li J, Rawson J, Omori K, Tai YC, Kandeel F, Mullen Y
    Transpl Int. 2020 07; 33(7):806-818.; 
    PubMed
  23. Semi-Automated Assessment of Human Islet Viability Predicts Transplantation Outcomes in a Diabetic Mouse Model.
    Salgado M, Gonzalez N, Medrano L, Rawson J, Omori K, Qi M, Al-Abdullah I, Kandeel F, Mullen Y, Komatsu H
    Cell Transplant. 2020 Jan-Dec; 29:963689720919444.; 
    PubMed
  24. Isolated pancreatic islet yield and quality is inversely related to organ donor age in rats.
    Gonzalez N, Salgado M, Medrano L, Mullen Y, Komatsu H
    Exp Gerontol. 2019 12; 128:110739.; 
    PubMed
  25. Optimizing Temperature and Oxygen Supports Long-term Culture of Human Islets.
    Komatsu H, Rawson J, Medrano L, Cook CA, Barriga A, Gonzalez N, Salgado M, Omori K, Kandeel F, Tai YC, Mullen Y
    Transplantation. 2019 02; 103(2):299-306.; 
    PubMed
  26. Oxygen transporter for the hypoxic transplantation site.
    Komatsu H, Cook CA, Gonzalez N, Medrano L, Salgado M, Sui F, Li J, Kandeel F, Mullen Y, Tai YC
    Biofabrication. 2018 12 07; 11(1):015011.; 
    PubMed
  27. Surfactants Improve Live Cell Imaging of Human Pancreatic Islets.
    Komatsu H, Omori K, Kandeel F, Mullen Y
    Pancreas. 2018 10; 47(9):1093-1100.; 
    PubMed
  28. Impact of Oxygen on Pancreatic Islet Survival.
    Komatsu H, Kandeel F, Mullen Y
    Pancreas. 2018 May/Jun; 47(5):533-543.; 
    PubMed
  29. Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival.
    Komatsu H, Cook C, Wang CH, Medrano L, Lin H, Kandeel F, Tai YC, Mullen Y
    PLoS One. 2017; 12(8):e0183780.; 
    PubMed
  30. Oxygenated thawing and rewarming alleviate rewarming injury of cryopreserved pancreatic islets.
    Komatsu H, Barriga A, Medrano L, Omori K, Kandeel F, Mullen Y
    Biochem Biophys Res Commun. 2017 05 06; 486(3):817-823.; 
    PubMed
  31. Determination of Islet Viability Using a Zinc-Specific Fluorescent Dye and a Semiautomated Assessment Method.
    Komatsu H, Omori K, Parimi M, Rawson J, Kandeel F, Mullen Y
    Cell Transplant. 2016 10; 25(10):1777-1786.; 
    PubMed
  32. Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming.
    Omori K, Kobayashi E, Komatsu H, Rawson J, Agrawal G, Parimi M, Oancea AR, Valiente L, Ferreri K, Al-Abdullah IH, Kandeel F, Takahashi M, Mullen Y
    Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1016-26.; 
    PubMed
  33. Isolated human islets require hyperoxia to maintain islet mass, metabolism, and function.
    Komatsu H, Kang D, Medrano L, Barriga A, Mendez D, Rawson J, Omori K, Ferreri K, Tai YC, Kandeel F, Mullen Y
    Biochem Biophys Res Commun. 2016 Feb 12; 470(3):534-538.; 
    PubMed
  34. Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors.
    Komatsu H, Egawa S, Motoi F, Morikawa T, Sakata N, Naitoh T, Katayose Y, Ishida K, Unno M
    Surg Today. 2015 Mar; 45(3):297-304.; 
    PubMed
  35. A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.
    Komatsu H, Tanji E, Sakata N, Aoki T, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M, Furukawa T
    PLoS One. 2014; 9(2):e87875.; 
    PubMed
  36. Fulminant type of emphysematous pancreatitis has risk of massive hemorrhage.
    Komatsu H, Yoshida H, Hayashi H, Sakata N, Morikawa T, Onogawa T, Motoi F, Rikiyama T, Katayose Y, Egawa S, Hirota M, Shimosegawa T, Unno M
    Clin J Gastroenterol. 2011 Aug; 4(4):249-254.; 
    PubMed